Belinostat (PXD101) Catalog No.:M22445-C [O-]S(=O)(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO

[O-]S(=O)(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO

Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux

The COX-2 inhibitor SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model

InChiKey: PLVGDGRBPMVYPB-FDUHJNRSSA-N

at 6x10-8 M

Belinostat (PXD101) Catalog No.:M22445-C [O-]S(=O)(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)COBelinostat (also known as PXD101) is a novel and potent hydroxamate type inhibitor of histone deacetylase (HDAC) that inhibits the activity of HDAC in Hela cell extracts with 50% inhibition concentration IC50 value of 27 nM. Belinostat has been found to significantly increase the acetylation of histones H3 and H4 and exerts cytotoxicity in a wide range of tumor cell lines. In the treatment of urothelial carcinoma cell lines, belinostat dose