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2- c]pyridin-5(6H)-yl)ethanone
It also decreases expression of HIF-1α and VEGF in breast cancer and glioma cells
which directly correlated with the observed inhibition of transport activity
CAS Number: 925434-55-5
InChiKey: JPMOKRWIYQGMJL-UHFFFAOYSA-N
SGI-110 Size:Solid 10 mg 2- c]pyridin-5(6H)-yl)ethanoneGuadecitabine, aslo known as SGI 110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI 110 inhibits DNA methyltransferase, thereby causing genome wide and non specific hypomethylation and inducing cell cycle arrest at S phase. This agent is resistant to cytidine deaminase, hence may
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