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Formula: C32H34Cl3F2N3O2
as well as improve insulin sensitivity and renal function in certain hypertensive or diabetic conditions
In cell cultures as well as in animal models
Chemical Name: 3-(Dimethylaminomethyl)indole
(2013) J Med Chem
CB-6644 - CAS# 2316817-88-4 BI-98782 Formula: C32H34Cl3F2N3O2CB 6644 is a novel allosteric selective inhibitor of the ruvbl1 2 complex with anti cancer activity. CB 6644 blocks the ATPase activity of RUVBL1 2 with an IC50 of 15 nM. CB 6644 interacts specifically with RUVBL1 2 in cancer cells, leading to cell death. Importantly, drug acquired resistant cell clones have amino acid mutations in either RUVBL1 or RUVBL2, suggesting that cell killing is an on target consequence of RUVBL1 2 engagement. In xenograft