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this agent is highly polyglutamylated and competes for the folate binding site of DHFR
In a xenograft model of nude mice
Smiles: NC(=N)NCCC(O)=O
InChiKey: OVAGJAAQMBYZDS-FXSDFHGDSA-N
InChiKey: XVARCVCWNFACQC-RKQHYHRCSA-N
LY 2389575 hydrochloride 17454 this agent is highly polyglutamylatedLY2389575 is described here instead of LY2389575 hydrochloride. LY2389575 is a selective negative allosteric modulator (NAM) of metabotropic glutamate receptor 3 (mGlu3) with an IC50 value of 4. 2 M . The metabotropic glutamate receptors (mGlus) are members of the GPCR family C. They are characterized by a large extracellular amino terminal domain for binding agonist. Eight mGlus had been found and were assigned to three groups based on their
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