Melphalan 195 Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)COC2=CC(=CC=C2)[C@@H](CCC2=CC(OC)=C(C=C2)OC)OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](CC)C2C=C(OC)C(OC)=C(C=2)OC)C(C)(C)C)=CC=1

Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)COC2=CC(=CC=C2)[C@@H](CCC2=CC(OC)=C(C=C2)OC)OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](CC)C2C=C(OC)C(OC)=C(C=2)OC)C(C)(C)C)=CC=1

[Epub ahead of print] PubMed PMID: 22575238

Termination phase III development of TAK-875 (Fasiglifam) for the potential treatment of type-2 diabetes mellitus was announced in 2013 due to concerns about liver safety

Chemical Name: 4-(2-((4-(2-(pyridin-2-yl)-5

4-benzothiadiazine-7-sulfonamide

Melphalan 195 Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)COC2=CC(=CC=C2)[C@@H](CCC2=CC(OC)=C(C=C2)OC)OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](CC)C2C=C(OC)C(OC)=C(C=2)OC)C(C)(C)C)=CC=1Melphalan is an orally available phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter strand cross linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non dividing tumor cells. Product information CAS Number: 148 82 3 Molecular Weight: 305. 20 Formula: C13H18Cl2N2O2 Synonym: Alkeran Sarcolysin L PAM