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is a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist with good pharmacokinetic properties
74(1):116-24
Fletcher D
Compared with vehicle-treated control tumors (n=15)
Duvelisib in indolent non-Hodgkin lymphoma
TAS-116 - CAS# 1260533-36-5 Catalog No.:M6713-10 is a selective and irreversibleTAS 116, CAS No. 1260533 36 5, also known as Pimitespib, is a potent and selective inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo radiosensitizing activities. TAS 116 specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent signaling, induces apoptosis, and