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Epub 2012 Jun 26
Epub 2015 Apr 20
dose-dependent reduction of phosphorylation of FGFR4 signaling pathway components
tumor growth inhibition increases with increased exposure of the compound and that tumor regressions could only be achieved when the compound exposure consistently exceeded 90% of c-MET inhibition
Combining P5091 with lenalidomide
A66 - CAS# 1166227-08-2 Catalog No.:M7134-10 Epub 2012 Jun 26A66, CAS No. 1166227 08 2, is a potent and highly selective p110 inhibitor with IC50 of 32 nM in a cell free assay, >100 fold selectivity for p110 over other class I PI3K isoforms. A66 blocks phosphoinositide 3 kinase signalling and tumour growth in certain cell types. Product information CAS Number: 1166227 08 2 Molecular Weight: 393. 53 Formula: C17H23N5O2S2 Synonym: A66 A 66 A 66 Chemical Name: (S) N1 (2 (tert butyl) 4' methyl [4,5' bithiazol] 2'
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