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1186/s12974-015-0363-z
6R)-4-amino-3
tumor growth and invasion
25)/t9-/m1/s1
Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT
CCG-63802 - CAS# 620112-78-9 Catalog No.:M10963-2 1186/s12974-015-0363-zCCG 63802 is a potent and reversible inhibitor of RGS protein. CCG 63802 inhibits the interaction between RGS4 and Galpha(o) with an IC(50) value in the low micromolar range. CCG 63802 shows selectivity among RGS proteins with a potency order of RGS 4 > 19 = 16 > 8 >> 7. CCG 63802 inhibits the GTPase accelerating protein activity of RGS4, and thermal stability studies demonstrate binding to the RGS but not to Galpha(o). CCG 63802 represents a useful
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