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Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders
Chemical Name: 5-{2-ethoxy-5-[(2
Hideshima T et al
6-Aminochrysene is an inhibitor of the growth of several solid experimental tumours in vivo and has a cancerostatic effect on human breast cancer
InChi: InChI=1S/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H
PROTAC BRD4 Degrader-14 cinimide sodium Potent and Preferential Degradation ofPROTAC BRD4 Degrader 14 is a PROTAC connected by ligands for von Hippel Lindau and BRD4, with IC50s of 1. 8 nM and 1. 7 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader 14 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells. Product information Molecular Weight: 1150. 27 Formula: C57H61F2N9O11S2 Chemical Name: 8 (3,5 difluoropyridin 2 yl) N (2 {3 hydroxy 5 [2 ({[(2S) 1 [(2S,4R) 4 hydroxy 2 ({[4 (4 methyl 1,3
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