TAS-116 binds not only to the conventional-binding pockets as existing Hsp-90 inhibitors
Azeliragon (4 nM
the identification of PKC412-resistant leukemic blast cells in the bone marrow of AML patients has propelled the development of novel and structurally distinct FLT3 inhibitors that have the potential to override drug resistance and more efficiently prevent disease progression or recurrence
and inhibit xenograft tumor growth in vivo
28(1):42-56
8-Oxocoptisine Catalog No.:M17106-C TAS-116 binds not only to8 Oxocoptisine is a natural protoberberine alkaloid with anti cancer activity. Product information CAS Number: 19716 61 1 Molecular Weight: 335. 31 Formula: C19H13NO5 Chemical Name: 5,7,17,19 tetraoxa 13 azahexacyclo[11. 11. 0. 0,. 0,. 0,. 0,]tetracosa 1(24),2,4(8),9,15,20,22 heptaen 14 one Smiles: O=C1C2=C3OCOC3=CC=C2C=C2C3=CC4OCOC=4C=C3CCN21 InChiKey: UCAFJBSQKXVPDX UHFFFAOYSA N InChi: InChI=1S C19H13NO5 c21 19 17 11(1 2 14 18(17)25 9 22 14)5 13 12