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IW-2143) is a negative allosteric modulator of alpha-7 nicotinic acetylcholine receptor (α7 nAChR)
Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model
and S-(2-(acylamino)phenyl) alkanethioates as novel inhibitors of cholesteryl ester transfer protein
R59022 (10 μM) potentiates aggregation
6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzene-1-sulfonamide
A-966492 Size:2mg solid IW-2143) is a negative allostericA 966492 is a potent PARP inhibitor, which displayed excellent potency against the PARP 1 enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. In addition, A 966492 is orally bioavailable across multiple species, crosses the blood brain barrier, and appears to distribute into tumor tissue. It also demonstrated good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX 1 breast
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