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4-benzotriazin-7-yl]phenyl benzoate
ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor
CAS Number: 134978-97-5
AS601245 (0
iso-Steviol
SD-36 Catalog No.:M13867-2 4-benzotriazin-7-yl]phenyl benzoateSD 36 is a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD 36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD 36 exerts robust anti tumor activity, and achieves complete and long lasting tumor regression in mouse tumor models. SD 36 is composed of the STAT3 inhibitor SI 109, a linker, and an analog of
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